HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7
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چکیده
منابع مشابه
ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages
The mammalian ATP-binding cassette transporters A1 and A7 (ABCA1 and -A7) show sequence similarity to CED-7, a Caenorhabditis elegans gene that mediates the clearance of apoptotic cells. Using RNA interference or gene targeting, we show that knock down of macrophage ABCA7 but not -A1 results in defective engulfment of apoptotic cells. In response to apoptotic cells, ABCA7 moves to the macrophag...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2011
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2011.06.031